Integrin beta 4 Protein (ITGB4) (AA 28-710) (His tag)

N° du produit ABIN7281344

Cette protéine Recombinant Integrin beta 4 est produite dans Baculovirus infected Insect Cells.

Aperçu rapide pour Integrin beta 4 Protein (ITGB4) (AA 28-710) (His tag) (ABIN7281344)

Antigène: Integrin beta 4 (ITGB4)

Type de proteíne: Recombinant

Origine: Humain

Source: Baculovirus infected Insect Cells

Application: SDS-PAGE (SDS)

Pureté: > 90 %

Détail du produit

Attributs du protein: AA 28-710

Purification/Conjugué: Cette Integrin beta 4 protéine est marqué à la His tag.

Séquence: NRCKKAPVKS CTECVRVDKD CAYCTDEMFR DRRCNTQAEL LAAGCQRESI VVMESSFQIT EETQIDTTLR RSQMSPQGLR VRLRPGEERH FELEVFEPLE SPVDLYILMD FSNSMSDDLD NLKKMGQNLA RVLSQLTSDY TIGFGKFVDK VSVPQTDMRP EKLKEPWPNS DPPFSFKNVI SLTEDVDEFR NKLQGERISG NLDAPEGGFD AILQTAVCTR DIGWRPDSTH LLVFSTESAF HYEADGANVL AGIMSRNDER CHLDTTGTYT QYRTQDYPSV PTLVRLLAKH NIIPIFAVTN YSYSYYEKLH TYFPVSSLGV LQEDSSNIVE LLEEAFNRIR SNLDIRALDS PRGLRTEVTS KMFQKTRTGS FHIRRGEVGI YQVQLRALEH VDGTHVCQLP EDQKGNIHLK PSFSDGLKMD AGIICDVCTC ELQKEVRSAR CSFNGDFVCG QCVCSEGWSG QTCNCSTGSL SDIQPCLREG EDKPCSGRGE CQCGHCVCYG EGRYEGQFCE YDNFQCPRTS GFLCNDRGRC SMGQCVCEPG WTGPSCDCPL SNATCIDSNG GICNGRGHCE CGRCHCHQQS LYTDTICEIN YSAIHPGLCE DLRSCVQCQA WGTGEKKGRT CEECNFKVKM VDELKRAEEV VVRCSFRDED DDCTYSYTME GDGAPGPNST VLVHKKKDCP PGS

Purification: > 90% by SDS-PAGE

niveau d'endotoxine: < 1 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) containing 10 % glycerol

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: Integrin beta 4 (ITGB4)

Autre désignation: Integrin beta 4/CD104

Sujet: ITGB4, also known as integrin beta-4 isoform 1, is a member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha 6 and participates in the formation of epithelial hemidesmosomes. This protein plays a critical structural role in the hemidesmosome of epithelial cells and is required for the regulation of keratinocyte polarity and motility. The heterodimer of them binds to NRG1 and this binding is essential for NRG1-ERBB signaling and binds to IGF1 and this binding is essential for IGF1 signaling. It tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Recombinant human ITGB4 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 77.5 kDa (691aa)

NCBI Accession: NP_000204

Pathways: Integrin Complex